Trypanocidal action and toxicity to enzymes

Cxxvii. Trypanocidal Action and Toxicity to Enzymes

Enzymes and Drug Action

Structure and action mechanism of ligninolytic enzymes.

Lignin is the most abundant renewable source of aromatic polymer in nature, and its decomposition is indispensable for carbon recycling. It is chemically recalcitrant to breakdown by most organisms because of the complex, heterogeneous structure. The white-rot fungi produce an array of extracellular oxidative enzymes that synergistically and efficiently degrade lignin. The major groups of ligni...

Pyrimidine Salvage in Trypanosoma brucei Bloodstream Forms and the Trypanocidal Action of Halogenated Pyrimidines s

African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host. However, uptake of pyrimidines in bloodstream form trypanosomes has not been investigated, making it difficult to judge the relative importance of salvage and synthesis or to design a pyrimidine-based chemotherapy. Detailed characterization of pyrimidine transport activities in b...

An Introduction to Action Research

سخن سردبیر Editorial مجله دانشگاه علوم پزشکی رفسنجان دوره 18، تیر 1398، 323-324             مقدمه‌ای بر پژوهش عملیاتی   An Introduction to Action Research     محسن رضائیان[1]   M.Rezaeian   کرت لوین (1947-1890) Kurt Lewin را بنیانگذار پژوهش عملیاتی Action Research می‌دانند. کاربردی که وی از پژوهش عملیاتی در نظر داشت عبارت بود از: پاسخ‌گویی به یک مسأله اجتماعی که با مشارکت فعا...